Natural behaviors in the laboratory

 We devise experiments that recapitulate the natural behaviors of the bat in the laboratory. In one paradigm, bats are trained to tracking moving targets from a stationary position. With this system, high fidelity measurements of vocalizations and motion of the external auditory system can be performed for highly controlled target motion conditions.

  As the bat tracks and intercepts targets, we perform multi-channel brain recordings to understand feedback loops between sensing and action.

  While the bat adapts behavior to successfully track and intercept targets, we can manipulate both motor and sensory signals to alter feedback loops.

  In order to test how different circuit components contribute to adaptive behavioral control, we also perform cell-specific optogenetics using a wireless device. Optical stimulation can be timed with echo feedback, vocal production, or target motion/position.

  The bat is an excellent model for how the brain operates in the real, 3D environment. We will perform multi-channel wireless physiology while the bat searches and intercepts targets to understand the integration of sensory and motor signals for the control of behavior.

  In order to understand how different circuits contribute to the bat's 3D behaviors, we will combine wireless multi-channel physiology with optogenetics so that we can turn on and off different circuit components with chronic neurophysiology while the bat performs its natural behaviors.